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077CYP450 2D6 substrateNon-substrate0. 117CYP450 3A4 substrateSubstrate0. 186CYP450 1A2 substrateNon-inhibitor0. 089CYP450 2C9 inhibitorInhibitor0.
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As evident from the clinical studies, dutasteride may also cause decreases in serum PSA in the presence of prostate cancer. 5 Following oral administration of a single dose of 0.In men with prostate volumes 40 cc, the mean decrease was -3. units for dutasteride and -2.
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3.In controlled clinical trials, dutasteride reduced avodart for hair growth concentrations of PSA by approximately 50% within 3-6 months following initiation of therapy; the mean decrease in serum total PSA concentration in patients receiving dutasteride was about 40% after 3 months of treatment and about 50% after. and 48 months of treatment.
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Concomitant administration of dutasteride with calcium-channel blocking agents that inhibit the cytochrome P-450 CYP 3A4 isoenzyme i. diltiazem, verapamil decreases dutasteride clearance resulting in increased exposure to dutasteride.Dutasteride is extensively metabolized in humans by the cytochrome P450 CYP A4 and CYP3A5 isoenzymes. The effect of potent CYP3A4 inhibitors on dutasteride has not been studied.
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