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Clinical data
PronunciationParacetamol: / ˌ p ær ə ˈ s iː t ə m ɒ l / Acetaminophen: / ə ˌ s iː t ə ˈ m ɪ n ə f ɪ n / ( listen )
Trade namesTylenol, Panadol, others [2]
License dataUS   FDA: Acetaminophen
Pregnancy categoryAU: A US: C (Risk not ruled out) [1] Not tested but seems to be safe
Routes of administrationBy mouth, through the cheek, rectal, intravenous (IV)
ATC codeN02BE01 ( WHO )
Legal status
Legal statusAU: S4 (Rx), OTC, and unscheduled UK: General sales list (GSL, OTC) US: OTC
Pharmacokinetic data
Bioavailability63–89% [4] : 73
Protein binding10–25% [5]
MetabolismPredominantly in the liver [3]
MetabolitesAPAP gluc, APAP sulfate, APAP GSH, APAP cys, NAPQI [6]
Onset of actionPain relief onset by route: By mouth – 37 minutes [7] Buccal – 15 minutes [7] Intravenous – 8 minutes [7]
Elimination half-life1–4 hours [3]
ExcretionUrine (85–90%) [3]

Biochem Biophys Res Commun. 2002 Mar. 089-94.

A celecoxib other names of 22 studies were included, 8 of which compared IV acetaminophen with an active comparator, and 14 of which compared IV acetaminophen with placebo. T-20see Enfuvirtide Injection; T-Gesic ® as a combination product containing Acetaminophen , Hydrocodonesee Hydrocodone Combination ... MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH.

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Levelandclinic. rghealthdiseases_conditionshic_Tension-Type_Headaches 2. Diener HC, Esterification M, Hagen M. Use of a strange can celecoxib be taken with acetaminophen of acetylsalicylic acid, acetaminophen and bedding compared with acetaminophen alone in abnormal tension-type headache: janice-analysis of four randomized, twisted-blind, coloured-controlled, reorder studies.

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Although the mechanism of acetaminophen toxicity is well recognized, the clinical implications of age-related differences and the ontogeny of hepatic pathways may not be commonly appreciated.National Institute for Health and Care Excellence NICE February 2018.

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Guggenheimer J, Moore PA. The therapeutic applications of and risks associated with acetaminophen use: a review and update.PMID. JS 1993 "Acetaminophen hepatotoxicity: potentiation by isoniazid".

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This is especially important if a new headache occurs within 1 day after you took your last dose of this medicine, headaches begin to occur every day, or a headache continues for several days in a row. This may mean that you are dependent on the medicine.Clin Toxicol Phila 2012 Jan. 6. Medline.

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Multum's drug information does not endorse drugs, diagnose patients or recommend therapy.2011 Sep. 2-30. Medline.

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Symptoms of overdose may include: slow/shallow breathing, nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, slow heartbeat, extreme tiredness, yellowing eyes/skin, dark urine, coma. Do not share this medication with others.There were infrequent reports of life-threatening anaphylaxis requiring emergency medical attention.

Instruct patients to discontinue PERCOCET immediately and seek medical care if they experience these symptoms.


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