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Clomipramine
Clinical data
Trade namesAnafranil, Clomicalm, others
AHFS/Drugs.comMonograph
MedlinePlusa697002
License dataUS   FDA: Clomipramine
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationBy mouth, intravenous [1]
ATC codeN06AA04 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability~50% [3]
Protein binding96–98% [3]
MetabolismHepatic (CYP2D6) [3]
MetabolitesDesmethylclomipramine [3]
Elimination half-lifeCMI: 19–37 hours [3] DCMI: 54–77 hours [3]
ExcretionRenal (51–60%) [3] Feces (24–32%) [3]

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Children under 15 years of age had significantly lower plasma concentration/dose ratios, compared with adults.Monitor therapy St John's Wort: May enhance the serotonergic effect of Serotonergic Agents High Risk This could result in serotonin syndrome.

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The frequencies presented, therefore, represent the proportion of the 3525 individuals generic clomipramine for dogs to Anafranil who experienced an event of the type cited on at least one occasion while receiving Anafranil.This Medication Guide is only about the risk of suicidal thoughts and actions with antidepressant medicines. Talk to your, or your family member's, healthcare provider about: Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions.

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23.Data sources include IBM Watson Micromedex updated 10 Aug 2020 Cerner Multum updated 3 Aug 2020 Wolters Kluwer updated 10 Aug 2020 andothers. rugs like this one have raised the chance of suicidal thoughts or actions in children and young adults.

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