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    MmHg amlodipine effective time on the 2.However, both were shown to induce chromosomal aberrations in cultured cells in vitro Chinese hamster lung and tested positive for thymidine kinase mutations in the in vitro mouse lymphoma assay. Olmesartan medoxomil tested negative in vivo for mutations in the MutaMouse amlodipine effective time and kidney and for clastogenicity in mouse bone marrow micronucleus test at amlodipine effective time doses of up to 2000 mg/kg olmesartan not tested Fertility of rats was unaffected by administration of olmesartan at dose levels as high as 1000 mg/kg/day 240 times the MRHD in a study in which dosing was begun 2 female or 9 male weeks prior to mating.

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    There was no effect on the fertility of rats treated orally with amlodipine maleate males for 64 days and females for 14 amlodipine effective time prior to mating at doses up to 10 mg amlodipine/kg/day 8 times the amlodipine effective time recommended human dose3of 10 mg/day on a mg/m2 basis The antihypertensive efficacy of amlodipine besylate has been demonstrated in a total of 15 double-blind, placebo-controlled, randomized studies involving 800 patients on amlodipine besylate and 538 on placebo.

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    Accessed Aug. Wright JM, et al.heparin may lead to increases in serum potassium and in heart failure patients to increases in serum creatinine. If co-medication is considered necessary, monitoring of serum potassium is advisable.

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