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This is why we see a lower overall mortality in this trial and why we not only see no mortality benefit, but also no shock reversal benefit septic shock patients were excluded from the trial Hydrocortisone + fludrocortisone therapy vs drotrecogin alfa activated protein C vs combination of three drugs vs alternative to fludrocortisone placebo Drotrecogin alfa was alternative to fludrocortisone from the market, the trial continued with a two-group alternative to fludrocortisone design comparing hydrocortisone plus fludrocortisone vs respective placebos Originally, this trial was supposed to be 4 groups of 320 patients looking for a 10% difference.

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