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Nicotine
Clinical data
Trade namesNicorette, Nicotrol
AHFS/Drugs.comMonograph
Pregnancy categoryAU: D US: D (Evidence of risk)
Dependence liabilityPhysical: low–moderate Psychological: moderate–high [1] [2]
Addiction liabilityHigh [3]
Routes of administrationInhalation; insufflation; oral – buccal, sublingual, and ingestion; transdermal; rectal
ATC codeN07BA01 ( WHO ) QP53AX13 ( WHO )
Legal status
Legal statusUS: OTC and ℞ (prescription) [4]
Pharmacokinetic data
Protein binding<5%
MetabolismPrimarily hepatic: CYP2A6, CYP2B6, FMO3, others
MetabolitesCotinine
Elimination half-life1-2 hours; 20 hours active metabolite
ExcretionRenal, urine pH-dependent; [5] 10–20% (gum), 30% (inhaled); 10–30% (intranasal)
NFPA 704 fire diamond
1 4 0 The fire diamond hazard sign for nicotine. [115]
External image
An image showing Nick O'Teen fleeing from Superman, Comic Vine

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Nicotinell product names
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