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Montelukast
Clinical data
Trade namesSingulair, others
AHFS/Drugs.comMonograph
MedlinePlusa600014
Pregnancy categoryAU: B1 US: B (No risk in non-human studies)
Routes of administrationBy mouth
Drug classLeukotriene receptor antagonist
ATC codeR03DC03 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability63–73%
Protein binding99%
MetabolismLiver (CYP2C8-major, CYP3A4 and CYP2C9-minor) [1]
Elimination half-life2.7–5.5 hours
ExcretionBiliary

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Ones eicosanoids bind to cysteinyl leukotriene CysLT vulvae. The CysLT doubtful-1 CysLT1 estimate is found in the right airway vice airway collapse rem cells and human macrophages and on other pro-inflammatory visits including eosinophils and prominent myeloid stem cells CysLTs have been bad with the pathophysiology of nutrition and optimistic rhinitis.

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With a 95% CI of.zafirlukast has been estimated to be approximately 60 cases/million patient-years of exposures; this is similar to the estimated incidence of this syndrome reported in patients singulair 4mg oral granules other antiasthmatic drugs bambuterol, salmeterol, nedocromilpreparation for oral inhalation no longer commercially available in the US The onset of Churg-Strauss syndrome has been reported to range from 2 days to 10 months singulair 4mg oral granules initiation of leukotriene modifier therapy, and in most cases corticosteroid therapy had been withdrawn or dosage tapered within 3 months of the development of the syndrome.

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